TweetDeck

For all of you Twitter addicts TweetDeck makes managing your Twitter feeds easier. TweetDeck enables users to split their main feed (All Tweets) into topic or group specific columns allowing a broader overview of tweets. The default columns can contain All Tweets from your timeline, @replies directed to you and direct messages. The GROUP, SEARCH and REPLIES buttons then allow the user to make up additional columns populated from the live tweet information. Once created these additional columns will automatically update allowing the user to keep track of a twitter threads far easier.

Other Twitter clients include twhirl and TwitterFox for Firefox users.